Virtual Headache Specialist

New Daily Persistent Headache (NDPH)



  1. Since this is a continuous daily headache, the goal of treatment is focused on preventive therapy: What to take on a daily basis to try to lessen the frequency and/or severity of the headaches. Preventive medicines generally take 4-6 weeks to start working and 2-3 months for full effect, assuming the correct dose of the medication is reached. These are the medications used most commonly, although this is not an all- inclusive list.
    1. Anti-convulsant (Anti-seizure) medications:
      ---Topiramate (Topamax)
      ---Gabapentin (Neurontin)
      ---Zonisamide (Zonegran)
      ---Divalproex sodium (Depakote)
    2. Anti-depressant/Anti-anxiety medications:
      ---Amitriptyline (Elavil)
      ---Nortriptyline (Pamelor)
      ---Venlafaxine XR (Effexor XR)
      ---Desvenlafaxine (Pristiq)
      ---Duloxetine (Cymbalta)
    3. Anti-hypertensive (blood pressure) medications:
      ---Propranolol (Inderal)
      ---Timolol (Timol)
      ---Metoprolol (Toprol)
      ---Atenolol (Tenormin)
      ---Nadolol (Corgard)
      ---Lisinopril (Zestril)
      ---Candesartan (Atacand)
      ---Verapamil (Calan)
      ---Acetazolamide (Diamox)
    4. Biologics:
      ---Onabotulinum Toxin A (Botox)